21 September 2018
Search :
  More Information Dastmalchi

More Information


Personal Details

Name:  Siavoush Dastmalchi (Professor)

Head of Medicinal Chemistry Department and Director of Biotechnology Research Center


Address: School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran

Phone no : +98 (413) 337 2254/336 4038

Email :


dastmalchi.s@tbzmed.ac.ir; siavoush11@yahoo.com





Languages :

English and Farsi




PhD, University of Sydney, Australia



Masters (preliminary) University of Sydney, Australia



Pharm. D, Tabriz University of Medical Sciences, Iran

Employment Record

1990– present

Faculty member at the School of Pharmacy, Tabriz University of Medical Sciences, Iran


Pos-doctorial fellowship at the University of Newcastle, NSW, Australia

 Scholarships and Awards


Recipient of Letter of Commendation from Khwarizmi International Award festival (2008)

Winner of Advanced Technology Research Prize in Razi National Research Festival (2006)

PhD scholarship from Iranian Ministry of Health and Medical Education (1997-2000)


Research areas

 In my group we are involved in drug discovery in a multidisciplinary fashion using Biophysical (NMR, CD and fluorescent spectroscopy) studies on proteins, Biotechnology and Cell biology, Computer Aided Drug Discovery (Molecular modelling, drug design, QSAR and bioinformatics) and investigation of physico-chemical properties of drug molecules.


Teaching duties

1)      Pharmacy degree: Medicinal Chemistry I,  Medicinal Chemistry III,  Instrumental Analysis, Biotechnology,  Practical Statistics,  Practical Instrumental Analysis

2)      PhD in Medicinal Chemistry: Advanced Biochemistry,  Advanced Instrumental Analysis,  Advanced Medicinal Chemistry

3)      PhD in Pharmaceutical Biotechnology: Bioinformatics, Protein Chemistry

4)      PhD in Medical Biotechnology: Protein Engineering, Bioinformatics

5)      PhD in Pharmacology and Toxicology:  Computer in toxicology, Medicinal Chemistry

6)      MSc in Medical Biotechnology: Bioinformatics



Books and Book Chapters

1.    Dastmalchi, S., Hamzeh-Mivehroud, M., & Sokouti, B. (2016). Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery (pp. 1-358). Hershey, PA: IGI Global. doi:10.4018/978-1-5225-0115-2
2.    Dastmalchi, S., Hamzeh-Mivehroud, M., & Sokouti, B. (2016). Applied Case Studies and Solutions in Molecular Docking-Based Drug Design (pp. 1-327). Hershey, PA: IGI Global. doi:10.4018/978-1-5225-0362-0
3.    Sokouti, B., Church, W. B., Morris, M. B., & Dastmalchi, S. (2015). Structural and Computational Approaches in Drug Design for G Protein-Coupled Receptors. In M. Khosrow-Pour (Ed.), Encyclopedia of Information Science and Technology, Third Edition (pp. 479-489). Hershey, PA: Information Science Reference. doi:10.4018/978-1-4666-5888-2.ch046
4.    Hamzeh-Mivehroud, M., Sokouti, B., & Dastmalchi, S. (2015). An Introduction to the Basic Concepts in QSAR-Aided Drug Design. In K. Roy (Ed.), Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment (pp. 1-47). Hershey, PA: Medical Information Science Reference. doi:10.4018/978-1-4666-8136-1.ch001
5.    Hamzeh-Mivehroud, M., Sokouti, B., & Dastmalchi, S. (2015). Molecular docking at a glance. In S. Dastmalchi, M. Hamzeh-Mivehroud, B. Sokouti (Eds.), Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery (pp. 1-41). Hershey, PA: Medical Information Science Reference. doi:.ch001
6.    Jozan, J., Joyban, A., Hanaee, J. and Dastmalchi, S., (1996) Translation to Farsi: High Performance Liquid Chromatography, (1992) 2nd Edition, by Sandie Lindsay (Author), Analytical Chemistry by Open Learning series, John Barnes (Series Editor), ISBN-10: 0471931152

1.    Sokouti B, Rezvan F, Dastmalchi S. GPCRTOP v.1.0:  one-step web server for both predicting helical transmembrane segments and identifying G protein-coupled receptors. Curr Bioinform (2017) 12:80-84.
2.    Alizadeh AA, Hamzeh-Mivehroud M, Farajzadeh M, Dastmalchi S. Identification of novel peptides against TNF-alpha using phage display technique and in silico modeling of their modes of binding. Eur J Pharm Sci (2017) 96:490-498. 
3.    Farajzadeh MA, Yadeghari A, Dehghani H, Dastmalchi S. Determination of Pyridine as a Decomposition Product in Ceftazidime and Mouthwash Solution. Chromatographia (2017) 1-6.
4.    Raeisi S, Ghorbanihaghjo A, Argani H, Dastmalchi S, Ghasemi B, Ghazizadeh T, Rashtchizadeh N, Nemati M, Mesgari Abbasi M, Bargahi N, Samadi Kafil H, Vatankhah A. The effects of valsartan on renal glutathione peroxidase expression in alleviation of cyclosporine nephrotoxicity in rats. Transplantation. (2017) 6:119-124. PMID: 27479164
5.    Zarei O, Benvenuti S, Ustun-Alkan F, Hamzeh-Mivehroud M, Dastmalchi S. Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery. J Cancer Res Clin Oncol (2016)142:2429-2446. PMID: 27503093
6.    Jahanban-Esfahlan A, Dastmalchi S, Davaran S. A simple improved desolvation method for the rapid preparation of albumin nanoparticles. Int J Biol Macromol. (2016) 91:703-9. doi: 10.1016/. PMID: 27177461
7.    Tahghighi, A., Hamzeh-Mivehroud, M., Asadpour Zeynali, K., Foroumadi, A., and Dastmalchi, S. QSAR and docking studies on the (5-nitroheteroaryl-1,3,4-thiadiazole-2-yl) piperazinyl analogs with antileishmanial activity. J Chemometrics (2016)5:284–293. doi: 10.1002/cem.2789.
8.    Raeisi S, Ghorbanihaghjo A, Argani H, Dastmalchi S, Ghasemi B, Ghazizadeh T, Rashtchizadeh N, Nemati M, Mesgari Abbasi M, Bargahi N, Mota A, Vatankhah AM. Effects of Angiotensin II Receptor Blockade on Soluble Klotho and Oxidative Stress in Calcineurin Inhibitor Nephrotoxicity in Rats. Iran J Kidney Dis (2016)10: 358-363.
9.    Gasemloo S, Sohrabi MR, Khosravi M, Dastmalchi S, Gharbani P. Fabrication of sulfated nanofilter membrane based on carboxymethyl cellulose. Water Sci Technol (2016)74: 2611-2619. 
10.    Safary A, Moniri R, Hamzeh-Mivehroud M, Dastmalchi S. A strategy for soluble overexpression and biochemical characterization of halo-thermotolerant Bacillus laccase in modified E. coli. Journal of Biotechnology (2016)227:56–63.
11.    Abolhasani H, Dastmalchi S, Hamzeh-Mivehroud M, Daraei B, Zarghi A. Design, synthesis and biological evaluation of new tricyclic spiroisoxazoline derivatives as selective COX-2 inhibitors and study of their COX-2 binding modes via docking studies. Medicinal Chemistry Research (2016)25:858-869.
12.    Taziki S, Sattari MR, Dastmalchi S, Eghbal MA. Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes. Advanced pharmaceutical bulletin (2015)5:329-34.
13.    Sina M, Farajzadeh D, Dastmalchi S. Effects of Environmental Factors on Soluble Expression of a Humanized Anti-TNF-α scFv Antibody in Escherichia coli. Advanced Pharmaceutical Bulletin (2015)5:455–461.
14.    Hamzeh-Mivehroud M, Moghaddas-Sani H, Rahbar-Shahrouziasl M, Dastmalchi S. Identifying key interactions stabilizing DOF zinc finger-DNA complexes using in silico approaches. Journal of theoretical biology (2015)382:150-159.
15.    Alizadeh AA, Hamzeh-Mivehroud M, Dastmalchi S. Identification of Novel Single Chain Fragment Variable Antibodies Against TNF-α Using Phage Display Technology. Advanced Pharmaceutical Bulletin (2015)5:661-666.
16.    Alizadeh AA, Hamzeh-Mivehroud M, Dastmalchi S. Production and Purification of a Novel Anti-TNF-α Single Chain Fragment Variable Antibody. Advanced Pharmaceutical Bulletin (2015)5:667-72.
17.    Sokouti B, Rezvan F, Dastmalchi S. Applying random forest and subtractive fuzzy c-means clustering techniques for developing a novel G protein-coupled receptors discrimination method using pseudo amino acid composition. Mol. BioSyst. (2015)11:2364-72. DOI: 10.1039/C5MB00192G
18.    Alizadeh AA, Hamzeh-Mivehroud M, Farajzadeh M, Moosavi-Movahedi AA, Dastmalchi S. A Simple and Rapid Method for Expression and Purification of Functional TNF-α Using GST Fusion System. Curr Pharm Biotechnol. (2015) 16:707-15.
19.    Hallajzadeh J, Ghorbanihaghjo A, Argani H, Dastmalchi S, Rashtchizadeh N. Growth Arrest-specific 6 Protein and Matrix Gla Protein in Hemodialysis Patients. Iran J Kidney Dis. (2015) 9:249-55.
20.    Samiei M, Asgary S, Farajzadeh M, Bargahi N, Abdolrahimi M, Kananizadeh U, Dastmalchi S. Investigating the mutagenic effects of three commonly used pulpotomy agents using the ames test. Adv Pharm Bull. (2015) 5:121-5.
21.    Abolhasani H, Zarghi A, Hamzeh-Mivehroud M, Alizadeh AA, Shahbazi Mojarrad J, Dastmalchi S. In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies. Iran J Pharm Res (2015) 14:141-147.
22.    Abolhasani H, Zarghi A, Abolhasani A, Hamzeh-Mivehroud M, Bargahi N, Notash B, Shahbazi Mojarrad J, Dastmalchi S. Design, Synthesis and in vitro Cytotoxicity Evaluation of New 3',4'-bis (3,4,5-trisubstituted)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one Derivatives as Promising Anticancer Agents. Lett Drug Des Dev (2014) 11:1149-1161.
23.    Sokouti B, Rezvan F, Yachdav G, Dastmalchi S. GPCRTOP: A Novel G Protein-Coupled Receptor Topology Prediction Method Based on Hidden Markov Model Approach using Viterbi Algorithm. Curr Bioinform (2014) 9:1-10. DOI: 10.2174/1574893609666140516010018.
24.    Hamzeh-Mivehroud M, Rahmani S, Feizi M-A, Dastmalchi S, Rashidi M-R. In vitro and in silico studies to explore structural features of flavonoids aldehyde oxidase inhibition. Arch Pharm Chem Life Sci (2014) 347, 1–10.
25.    Hamzeh-Mivehroud M, Alizadeh AA, Morris MB, Bret Church W, Dastmalchi S. Phage display as a technology delivering on the promise of peptide drug discovery. Drug Discov Today (2013) 18(23-24):1144-57.
26.    Nahaei M, Valizadeh H, Baradaran B, Nahaei MR, Asgari D, Hallaj-Nezhadi S, Dastmalchi S, Lotfipour F. Preparation and Characterization of Chitosan/β-cyclodextrin Nanoparticles Containing Plasmid DNA Encoding Interleukin-12. Drug Res (Stuttg) (2013) 63:7-12.
27.    Hamzeh-Mivehroud M, Rahmani S, Rashidi MR, Hosseinpour Feizi MA, Dastmalchi S. Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids. Xenobiotica (2013) 43:661-70.
28.    Dastmalchi S, Wilkinson-White LE, Kwan AH, Mackay JP, Matthews JM. Solution structure of a tethered Lmo2LIM2/Ldb1LID complex. Protein Science (2012) 21:1768-74.
29.    Tahghighi A, Emami S, Razmi S, Rezazade Marznaki F, Kabudanian Ardestani S, Dastmalchi S, Kobarfard F, Shafiee A, Foroumadi A. New 5-(nitroheteroaryl)-1,3,4-thiadiazols containing acyclic amines at C-2: synthesis and SAR study for their antileishmanial activity. J Enzyme Inhib Med Chem (2013) 28:843-52.
30.    Mehrizad A, Zare K, Aghaie H, Dastmalchi S. Removal of 4-chloro-2-nitrophenol occurring in drug and pesticide waste by adsorption onto nano-titanium dioxide. Int J Environ Sci Technol (2012) 9: 355 – 560.
31.    Mehrizad A, Aghaie M, Gharbani P, Dastmalchi S, Monajjemi M, Zare K. Comparison of 4-chloro-2-nitrophenol adsorption on single-walled and multi-walled carbon nanotubes. Iran J Environ Health Sci Eng (2012) 9: 5.
32.    Hassan M, Diep DB, Javadzadeh Y, Dastmalchi S, Nes IF, Sharifi Y, Yari S, Farajnia S, Lotfipour F. Prevalence of bacteriocin activities and bacteriocin-encoding genes in enterococcal clinical isolates in Iran. Can J Microbiol (2012) 58: 359-68.
33.    Tahghighi A, Razmi S, Mahdavi M, Foroumadi P, Ardestani SK, Emami S, Kobarfard F, Dastmalchi S, Shafiee A, Foroumadi A. Synthesis and anti-leishmanial activity of 5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amines containing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moieties. Eur J Med Chem (2012) 50:124-8.
34.    Hamzeh-Mivehroud M, Alizade A A, Ahmadifar M, Dastmalchi S. In silico Evaluation of Crosslinking Effects on Denaturant meq values and ΔCp upon Protein Unfolding. Avicenna J Med Biotech (2012) 4: 23-34.
35.    Werner T, Morris MB, Dastmalchic S, Church WB. Structural modelling and dynamics of proteins for insights into drug interactions. Advanced Drug Delivery Reviews (2012) 64:323-43.
36.    Dastmalchi S, Hamzeh-Mivehroud M, Asadpour-Zeynali K. Comparison of different 2D and 3D-QSAR methods on activity prediction of histamine H3 receptor antagonists. Iran J Pharm Res (2012) 11: 97-108.
37.    Javadzadeh Y, Adibkia K, Bozorgmehr Z, Dastmalchi S. Evaluating retardation and physicochemical properties of co-ground mixture of Na-diclofenac with magnesium stearate. Powder Tech (2011) 218:51-56.
38.    Hamzeh-Mivehroud M, Mahmoudpour A, Dastmalchi S. Identification of new peptide ligands to epidermal growth factor receptor using phage display method and computationally modeling their mode of binding. Chem Biol Drug Des (2011) 79: 246–259.
39.    Wilkinson-White LE, Gamsjaeger R, Dastmalchi S, Weinert B, Stokes PH, Crossley M, Mackay JP, Matthews JM. The structural basis of simultaneous recruitment of LMO2 and FOG1 by GATA1. PNAS (2011) 108, 14443-8.
40.    Zare B, Madadkar-Sobhani A, Dastmalchi S, Mahmoudian M. Prediction of the Human EP1 Receptor Binding Site by Homology Modeling and Molecular Dynamics Simulation. Sci Pharm (2011) 79, 793-816.
41.    Gharbani P, Tabatabaei SM, Dastmalchi S, Ataie S, Mosenharzandi A, Mehrizad A. Adsorption of chloroform from aqueous solution by nano -TiO2. Int J Nano Dim (2011) 1,287-296.
42.    Tabatabaei SM, Dastmalchi S, Mehrizad A, Gharbani P. Enhancement of 4-nitrophenol ozonation in water by nano Zn catalyst. Iran J Health Sci Eng (2011) 8:363-372.
43.    Hallaj-Nezhadi S, Valizadeh H, Dastmalchi S, Baradaran B, Barzegar Jalali M, Dobakhti F, LotfipourF. Preparation of Chitosan-Plasmid DNA Nanoparticles Encoding interleukin-12 and their Expression in CT-26 Colon Carcinoma Cells. J Pharm Pharmaceut Sci (2011) 14, 181 – 195.
44.    Adibkia Kh, Javadzadeh Y, Dastmalchi S, Mohammadi G, Kari Niri F, Alaei-Beiramia M. Naproxen–eudragit® RS100 nanoparticles: Preparation and physicochemical characterization. Colloids and Surfaces B: Biointerfaces (2011) 83, 155-159.
45.    Tahghighi A, Rezazade Marznaki F, Kobarfard F, Dastmalchi S, Shahbazi Mojarrad J, Razmi S, Kabudanian Ardestani S, Emami S, Shafiee A, Foroumadi A. Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1,3,4-thiadiazoles with piperazinyl-linked benzamidine substituents. Eur J Med Chem (2011) 46, 2602-2608.
46.    Wilkinson-White LE, Dastmalchi S, Kwan AH, Ryan DP, Mackay JP, Matthews JM. 1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex. Biomol NMR Assign (2010) 4, 203-206. 
47.    Soltani S, Dastmalchi S, Jouyban A. Prediction of electrophoretic mobility of analytes in capillary electrophoresis using molecular connectivity indices. Asian J Chem (2010) 22, 4727-4734.
48.    Gharbani P, Khosravi M, Tabatabaii SM, Zare K, Dastmalchi S, Mehrizad A. Degradation of trace aqueous 4-chloro-2-nitrophenol occurring in pharmaceutical wastewater by ozone. Int J Environ Sci Tech (2010) 7, 1735-1472.
49.    Zare B, Madadkar-Sobhani A, Dastmalchi S, Mahmoudian M. Modeling of the hEP1 receptor based on the crystallographic structure of β2-adrenergic receptor and its assessment with docking studies and molecular dynamics simulation. DARU (2009) 17, 299-307.
50.    Morris MB, Dastmalchi S, Church WB. Rhodopsin: Structure, signal transduction and oligomerisation. Int J Biochem Cell Biol (2009) 41, 721-724.
51.    Hamzeh-Mivehroud M, Mahmoudpour A, Rezazadeh H, Dastmalchi S. Non-specific translocation of peptide-displaying bacteriophage particles across the gastrointestinal barrier. Eur J Pharm Biopharm (2008) 70, 577-581.
52.    Dastmalchi S, Morris MB, Church WB. G protein-coupled receptor structure modeling aided by 3D validation. BMC Bioinformatics (2008) 9, S14.
53.    Dastmalchi S, Hamzeh-Mivehroud M, Ghafourian T, Hamzeiy H. Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists. J Mol Graph Model (2008) 26, 834-44.
54.    Dastmalchi S, Beheshti S, Morris MB, Church BW. Prediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analyses. FEBS J (2007) 274, 2653-60.
55.    Barzegar-Jalali M, Valizadeh H, Dastmalchi S, Siahi Shadbad MR, Barzegar-Jalali A, Adibkia KH, Mohammadi GH. Enhancing Dissolution Rate of Carbamazepine via Cogrinding with Crospovidone and Hydroxypropylmethylcellulose. Iranian J Pharm Res (2007) 6, 159-165.
56.    Barzegar-Jalali M, Dastmalchi S. Kinetic analysis of chlorpropamide dissolution from solid dispersions. Drug Dev Ind Pharm (2007) 33, 63-70.
57.    Nokhodchi A, Jelvehgari M, Siahi MR, Dastmalchi S. The effect of formulation type on the release of benzoyl peroxide from microsponges. Iranian J Pharm Sci (2006) 1, 131-142.
58.    Ghafourian T, Barzegar-Jalali M, Dastmalchi S, Khavari-Khorasani T, Hakimiha N, Nokhodchi A. QSPR models for the prediction of apparent volume of distribution. Int J Pharm (2006) 319, 82-97.
59.    Jelvehgari M, Nokhodchi A, Siahi MR, Dastmalchi S. Microencapsulation of benzoyl peroxide by suspension polymerization in liquid- liquid system method. Pharm Sci (2005) Autumn, 53-64.
60.    Hanaee J, Jouyban A, Dastmalchi S, Adibkia K, Mirzazadeh A, Barzegar-Jalali M. Solubility prediction of sulfonamides at various temperatures using a single determination. DARU (2005) 13, 37-45.
61.    Dastmalchi S, Hamzeh-Mivehroud M. Molecular modelling of human aldehyde oxidase and identification of the key interactions in the enzyme-substrate complex. DARU (2005) 13, 82-93.
62.    Dastmalchi S, Garjani A, Maleki N, Sheikhee G, Baghchevan V, Jafari-Azad P, Valizadeh H, Barzegar-Jalali M. Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique. J Pharm Pharm Sci (2005) 8, 175-81.
63.    Dastmalchi S, Church WB, Morris MB, Iismaa TP, Mackay JP. Presence of transient helical segments in the galanin-like peptide evident from (1)H NMR, circular dichroism, and prediction studies. J Struct Biol (2004) 146, 261-71.
64.    Dastmalchi S, Kobus FJ, Iismaa TP, Morris MB, Church WB. Comparison of the transmembrane helices of bovine rhodopsin in the crystal structure and the C template based on cryo-electron microscopy maps and sequence analysis of the G protein-coupled receptors. Mol Simulation (2002) 28, 845-851.
65.    Barzegar-Jalali M, Maleki N, Garjani A, Khandar AA, Haji-Hosseinloo M, Jabbari R, Dastmalchi S. Enhancement of dissolution rate and anti-inflammatory effects of piroxicam using solvent deposition technique. Drug Dev Ind Pharm (2002) 28, 681-6.
66.    Jouyban-Gharamaleki A, Dastmalchi S, Chan HK, Hanaee J, Javanmard A, Barzegar-Jalali M. Solubility prediction for furosemide in water-cosolvent mixtures using the minimum number of experiments. Drug Dev Ind Pharm (2001) 27, 577-83.
67.    Dastmalchi S, Morris MB, Church WB. Modeling of the structural features of integral-membrane proteins reverse-environment prediction of integral membrane protein structure (REPIMPS). Protein Sci (2001) 10, 1529-38.
68.    Dastmalchi S, Barzegar-Jalali M. Relationship between potency and boiling point of general anesthetics: a thermodynamic consideration. Int J Pharm (2000) 202, 41-5.
69.    Dastmalchi S, Rashidi MR, Rassi M. Simultaneous determination of the pKa and octanol/water partition coefficient (Pm) of acetaminophen. DARU (1995) 4, 7-14.