Name: Siavoush Dastmalchi (Associate Professor)
Head of Medicinal Chemistry Department and
Director of Biotechnology Research Center
Address: School of Pharmacy,
Tabriz University of Medical Sciences,
Tabriz 51664, Iran
Phone no : +98 (411) 337 2254/336 4038
English and Farsi
PhD, University of Sydney, Australia
Masters (preliminary) University of Sydney, Australia
Pharm. D, Tabriz University of Medical Sciences, Iran
Faculty member at the School of Pharmacy, Tabriz University of Medical Sciences, Iran
Pos-doctorial fellowship at the University of Newcastle, NSW, Australia
Scholarships and Awards
PhD scholarship from Iranian Ministry of Health and Medical Education (1997-2000)
Winner of Advanced Technology Research Prize in Razi National Research Festival (2006)
In my group we are involved in drug discovery in a multidisciplinary fashion using Biophysical (NMR, CD and fluorescent spectroscopy) studies on proteins, Biotechnology and Cell biology, Computer Aided Drug Discovery (Molecular modelling, drug design, QSAR and bioinformatics) and investigation of physico-chemical properties of drug molecules.
Dastmalchi S, Morris MB, Church WB. G protein-coupled receptor structure modeling aided by 3D validation. BMC Bioinformatics (2007) (submitted).
Dastmalchi S, Hamzeh-Mivehroud M, Ghafourian T, Hamzeiy H Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists. J Mol Graph Model (2007).
Dastmalchi S, Beheshti S, Morris MB, Bret Church W. Prediction of rotational orientation of transmembrane helical segments of integral membrane proteins using new environment-based propensities for amino acids derived from structural analyses. FEBS J (2007) 274, 2653-60.
Barzegar-Jalali M, Dastmalchi S. Kinetic analysis of chlorpropamide dissolution from solid dispersions. Drug Dev Ind Pharm (2007) 33, 63-70.
Nokhodchi A, Jelvehgari M, Siahi MR, Dastmalchi S. The effect of formulation type on the release of benzoyl peroxide from microsponges. Iranian J Pharm Sci (2006) 1, 131-142.
Ghafourian T, Barzegar-Jalali M, Dastmalchi S, Khavari-Khorasani T, Hakimiha N, Nokhodchi A. QSPR models for the prediction of apparent volume of distribution. Int J Pharm (2006) 319, 82-97.
Jelvehgari M, Nokhodchi A, Siahi MR, Dastmalchi S. Microencapsulation of benzoyl peroxide by suspension polymerization in liquid- liquid system method. Pharm Sci (2005) Autumn, 53-64.
Hanaee J, Jouyban A, Dastmalchi S, Adibkia K, Mirzazadeh A, Barzegar-Jalali M. Solubility prediction of sulfonamides at various temperatures using a single determination. DARU (2005) 13, 37-45.
Dastmalchi S, Hamzeh-Mivehroud M. Molecular modelling of human aldehyde oxidase and identification of the key interactions in the enzyme-substrate complex. DARU (2005) 13, 82-93.
Dastmalchi S, Garjani A, Maleki N, Sheikhee G, Baghchevan V, Jafari-Azad P, Valizadeh H, Barzegar-Jalali M. Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique. J Pharm Pharm Sci (2005) 8, 175-81.
Dastmalchi S, Church WB, Morris MB, Iismaa TP, Mackay JP. Presence of transient helical segments in the galanin-like peptide evident from (1)H NMR, circular dichroism, and prediction studies. J Struct Biol (2004) 146, 261-71.
Dastmalchi S, Kobus FJ, Iismaa TP, Morris MB, Church WB. Comparison of the transmembrane helices of bovine rhodopsin in the crystal structure and the Ca template based on cryo-electron microscopy maps and sequence analysis of the G protein-coupled receptors. Mol Simulation (2002) 28, 845-851.
Barzegar-Jalali M, Maleki N, Garjani A, Khandar AA, Haji-Hosseinloo M, Jabbari R, Dastmalchi S. Enhancement of dissolution rate and anti-inflammatory effects of piroxicam using solvent deposition technique. Drug Dev Ind Pharm (2002) 28, 681-6.
Jouyban-Gharamaleki A, Dastmalchi S, Chan HK, Hanaee J, Javanmard A, Barzegar-Jalali M. Solubility prediction for furosemide in water-cosolvent mixtures using the minimum number of experiments. Drug Dev Ind Pharm (2001) 27, 577-83.
Dastmalchi S, Morris MB, Church WB. Modeling of the structural features of integral-membrane proteins reverse-environment prediction of integral membrane protein structure (REPIMPS). Protein Sci (2001) 10, 1529-38.
Dastmalchi S, Barzegar-Jalali M. Relationship between potency and boiling point of general anesthetics: a thermodynamic consideration. Int J Pharm (2000) 202, 41-5.
Dastmalchi S, Rashidi MR, Rassi M. Simultaneous determination of the pKa and octanol/water partition coefficient (Pm) of acetaminophen. DARU (1995) 4, 7-14.