Head of laboratory: Dr. Amir Gorbanihaghjo
Overview of Biochemistry
The field of Biochemistry is one of the most vital and dynamic subjects of the science. Rooted in the traditional areas of metabolism and nutrition, biochemistry now extends to the newer fields of enzyme isolation, molecular structure, immunology and biological spectroscopy. It combines the molecular approach of chemistry with the vitality and diversity of biology. Biochemistry focuses on the interconversion of compounds in the many complex reactions of life, on the mechanisms whereby enzymes catalyze and regulate these reactions, and the function and the structure of the molecular components of living organisms. It continues to advance our understanding of how cells are constructed, how they function and communicate with each other, how genetic information is stored, expressed and passed on to the next generation and how all of the cell's chemistry is coordinated and controlled. Because it covers the spectrum of complexity from bacteria, yeasts and viruses to humans, and includes plants, biochemistry underpins other life sciences such as microbiology, physiology, zoology and botany as well as being a foundation subject for all the health sciences. This laboratory covers the following major research areas:
Oxidative stress and diseases
The relationships between oxidative stress and diseases like cardiovascular diseases are under investigation in biochemistry laboratory. Survey of oxidant agents such as 8OhdG, MDA, CD, Carbonyls, and Sulphydryls proteins, trace elements and oxidative stress is significantly important in evaluation affect of DNA, lipids, Carbohydrate proteins oxidation and trace elements in atherosclerosis development and its relation with Coronary, renal, other related diseases and understanding of pathological basis of these diseases.
Preparing laboratory kits
Preparing laboratory kits are very important in clinical diagnosis. Making different Immunochemical, Enzymatic, and Chemical kits require separation and purification of different enzymes and biomolecules by Chromatography, Electrophoresis, Immunoblotting, etc. methods. In this area the objective of biochemistry laboratory is designing and developing new methods for preparing laboratory kits.
Evaluation of genetic indicators
Association of genetic indicators such as Lp(a), apoA, Paraoxonase, phenotypes and genotypes phenotypes with some diseases like Coronary, artery diseases, Renal diseases and other related disorders are among major research topics of biochemistry laboratory.