The focus of our research is drug discovery using a variety of theoretical and experimental approaches. We are interested in modelling the structures of therapeutically important proteins particularly the cell surface membrane proteins. Recently, we have started to use the phage display technique as a powerful tool for drug design and drug delivery.
Integral-membrane proteins (IMPs) accomplish a variety of important cellular functions and make up a large fraction of all proteins (Goffeau et al. 1993; Jones 1998) reflecting the fact that they play critical roles in maintaining the homeostasis and responsiveness of cells, organs, and organisms. Although like all other proteins, the information necessary for the folding of IMPs are embedded in their sequences, however, the folding pathways may seem rather specific (Booth & Curran 1999).